Substance «Temozolomide»

Application area

Malignant glioma (glioblastoma multiforme, anaplastic astrocytoma) in the presence of recurrence or progression of the disease after standard therapy; common metastatic malignant melanoma (1st line therapy).

Pharmacological group

Antineoplastic agents, alkylating agents.

Main characteristics

  • Powder from white to white with light pink color;
  • It is practically insoluble in ethyl alcohol, very slightly soluble in water and in a 0.1 M solution of hydrochloric acid, moderately soluble in dimethyl sulfoxide;
  • pH from 5.0 to 7.0;
  • Heavy metals - no more than 20 ppm;
  • The content of the basic substance in the test substance should be from 98.0% to 102.0% calculated on the dry matter;

Release form

Powder packed in 0.1 kg cans of dark glass.

Expiration date

24 months.

Developed by

"Research Institute of Physical and Chemical Problems"

Intellectual Property Rights

Patents of the Republic of Belarus: № 16085, 15961

Eurasian patent: № 031596

Reg. authenticated №16/02/1829 of 02/23/2016, validity period: indefinitely.